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胡康洪

发布时间:2020-04-11 阅读人数:

导师姓名:胡康洪

导师类型:博士生导师

出生日期:1964/8/20

职称:教授

个人简介:

   二级教授,博导,德籍华人科学家,回国前是德国Regensburg大学教授。2008年全职回国,任中科院武汉病毒所国家重点实验室PI。长期从事病毒学和再生医学基础与应用研究。2013年起担任湖工大中德生物医学中心主任。迄今已发表学术论文170多篇,已培养博士、硕士30余名。教育部评审专家,湖北省特聘专家。

所在学院:生物工程与食品学院

专业:生物医学

研究方向:分子病毒学

主讲硕士生课程:代谢工程;Metabolic Engineering (留学生)

主讲博士生课程:代谢工程

科研项目:

1. 用SELEX技术体外筛选抗HBV的诱饵分子(国家自然科学基金面上项目 2009-2011)

2. HBV易感细胞系的建立与优化(“十一五”国家科技重大专项 2010-2011)

3. 现场及快速高灵敏传染病检测新技术(“十一五”国家科技重大专项 2010-2011)

4. 基于三维细胞培养系统的HBV感染细胞模型(“十二五”国家科技重大专项 2012-2015)

5. 运用三维培养模型进行短肽抗HBV药效学评价(“十二五”国家科技重大专项 2012-2015)

6. RNA诱饵抗HBV的体内功效研究(湖北省自然科学基金重点项目,2014CFA075,2015-2016)

科研成果:

代表性论文:

1. Feng H , Beck J, Nassal M and Hu K*. 2011 “A SELEX-Screened aptamer of human hepatitis B virus RNA encapsidation signal suppresses viral replication“ Plos One 6(11):e27862

2. 胡康洪参编《再生医学发展战略纲要》第十二章“生物材料”科学出版社

3. Zhao Z, Hong W, Zeng Z, Wu Y, Hu K et al. 2012 "Mucroporin-M1 inhibits hepatitis B virus replication by activating the MAPK pathawy and down-regulating HNF4α in vitro and in vivo" J BiolChem.287(36):30181-90.

4. Wang W, Peng H, Li J, Zhao X, Zhao F, Hu K* 2013 "Controllable inhibition of hepatitis B virus replication by a DR1-targeting short hairpin RNA (shRNA) expressed from a DOX-inducible lentiviral vector." Virus Genes 46(3):393-403.

5. Feng H, Chen P, Zhao F , Nassal M, Hu K* 2013 “Evidence for Multiple Distinct Interactions between Hepatitis B Virus P Protein and Its Cognate RNA Encapsidation Signal during Initiation of Reverse Transcription. Plos One 8:e72798.

6. Chen P, Yun G, Na H, Wei F, Li J, Zhao F, Rayner S*, Hu K. * 2013 "Computational evolutionary analysis of the overlapped surface (S) and polymerase (P) region in hepatitis B virus indicates the spacer domain in P is crucial for survival." PLoS One 8(4):e60098.

7. Pan X, Li XJ, Liu XJ, Tian XH, Hu KH.et al. 2013 Later Passage Neural Progenitor Cells from Neonatal Brain Are More Permissive for Human Cytomegalovirus Infection. Journal of Virology 87(20):10968-10979.

8. Tian X, Zhao F, Cheng Z, Zhou M, Zhi X, Li J, Hu K*. 2013 GCN5 acetyltransferase inhibits PGC1α-induced hepatitis B virus biosynthesis. Virol Sinica 28(4):216-22.

9. Zhou M, Zhao F, Li J, Cheng Z, Tian X, Huang Y, Zhi X and Hu K*. 2014 "Long-term maintenance of human fetal hepatocytes and prolonged susceptibility to HBV infection by co-culture with nonparenchymal cells" J Virol Methods 195:185-193

10. Zhou M, Huang Y, Cheng Z, Zhao F, Li J, Zhi X, Tian X, Sun W, Hu K* 2014 Revival, characterization, and hepatitis B virus infection of cryopreserved human fetal hepatocytes. J Virol Methods 207:29-37

11. Pan D, Lin Y, Wu W, Song J, Zhang E, Wu C, Chen X, Hu K et al. 2015 Persistent of recombinant genomes of woodchuck hepatitis virus in the mouse model. PlosOne10(5):e0125658

12. Cheng Z, Sun G, Guo W, Huang Y, Sun W, Zhao F, Hu K* 2015 Inhibition of hepatitis B virus replication by quercetin in human hepatoma cell lines. Virol Sinica 30(4):261-268.

13. Cheng ZK, Zhi XG, Sun G, Guo W, Zhao F, Hu KH* 2016 Sodium selenite suppresses hepatitis B virus transcription and replication in human hepatoma cell lines. J Med Virol. 88(4):653-663

14. Tian Xiaohui, Zhao Fei, Sun Weihua, Zhi Xiaoguang, Hu Kanghong* 2014 CRTC2 enhances HBV transcription and replication by inducing PGC1alpha expression. 11:30, doi: 10.1186/1743-422X-11-30.

15. Xiaoli Ye, Ming Zhou,Yonggang He,Yanmin Wan, WeiyaBai, Shuai Tao, YanqinRen, Xinxin Zhang, JianqingXu, Jing Liu, Junqi Zhang, Kanghong Hu* et al. 2016 "Efficient Inhibition of Hepatitis B Virus Infection by a preS1-binding Peptide” Scientific Reports 6:29391DOI: 10.1038/srep29391

16. Mengying Ji and Kanghong Hu* 2017 "Recent advances in the study of hepatitis B virus covalently closed circular DNA" Virologica Sinica 32(6):454-464

17. Yao Chengguang, Xi Caili, Hu Kanghong et al. 2018 "Inhibition of enterovirus 71 replication and viral 3C protease by quercetin"Virology Journal 15(1):116. doi: 10.1186/s12985-018-1023-6.

18. Min Chen, Ni Li, Nan Wang, Hu Kanghong et al. 2018 "Synthesis, structure and antitumor studies of a novel decavanadate complex with a wavelike two-dimensional network"Polyhedron 155:313-319.

19. Yao Chengguang#, Hu Kanghong# et al. 2019 "Transcriptomic analysis of cells in response to EV71 infection and 2Apro as a trigger for apoptosis via TXNIP gene" Genes & Genomics 41(3):343-357. doi: 10.1007/s13258-018-0760-7

20. Xiaokang Hu, Huan Wang, Bo Huang, Ni Li, Kanghong Hu* et al. 2019 "A new scheme for rational design and synthesis of polyoxovanadate hybrids with high antitumor activities"Journal of Inorganic Biochemistry 193:130-132

21. Wei Yanhong, Wang Haijie, Xi Caili, Li NI, Li Dong, Yao Chengguang, Sun Ge, Ge Hongmei, Hu Kanghong*, Zhang Qian* 2020 "Antiviral effects of novel 2-benzoxyl-phenylpyridine derivatives" Molecules 25, 1409; doi:10.3390 / molecules25061409



专利

1. 胡康洪等“一种抗HBV诱饵适体及其筛选方法”发明专利授权号:ZL 201110410737.7

2. 胡康洪等“利用慢病毒载体介导RNAi的方法”发明专利授权号:ZL 201110110644.2

3. 胡康洪等“人原代肝细胞与肝非实质细胞共培养方法”发明专利授权号:ZL 201310282851.5

4. 胡康洪“三维灌流式细胞培养器及其应用”发明专利授权号:ZL 201410024728.8

5. 胡康洪“N-甲酰基-3,4-亚甲二氧基苄基-γ-丁内酯在制备抗乙型肝炎病毒药物中的应用”发明专利授权号:ZL 201610407438.0

6. 胡康洪“一种批量简易移液枪头装盒装置”发明专利授权号:ZL 201510596259.1

7. 魏艳红,胡康洪等“吡啶杂环酯类化合物在制备抗柯萨奇病毒B3型的药物中的应用”发明专利授权号:ZL 201611192749.6

8. 魏艳红,胡康洪等“芳香酯类化合物在制备抗肠道病毒71型药物中的应用”发明专利授权号:ZL 201611192748.1

9. 胡康洪“一种三维灌流式细胞分离器”实用新型专利授权号:ZL 201420033628.7

10. 胡康洪等“一种酶标板清洗器”实用新型专利授权号:ZL201620514335.X

11. 胡康洪等“一种用于深层挫裂伤的免缝合式医用拉链”实用新型专利授权号:ZL 201420699686.3

12. 胡康洪等“一种复合维生素营养霜及其脂质体包覆物的制备方法”发明专利申请号:ZL 201710201247.3

13. 胡康洪等“一种对HBV易感的人胎肝细胞分离、冻存与复苏方法及应用”发明专利申请号:ZL 201410009255.4

14.胡康洪等“亚硒酸钠在制备治疗或预防乙型肝炎病毒感染药物中的应用”发明专利申请号:ZL 201410009255.4



获奖

1. 1990 中国科协优秀学术论文 二等奖

2. 1995-1997 德国Friedrich-Ebert-基金会 博士奖学金

3. 2006-至今 德国Friedrich-Ebert-基金会生命科学奖学金生 导师

4. 2007 德国细胞生物学会创新奖

5. 2009起 ISRN Tissue Engineering、Virology & Retro Virology、Pathogens & Infectious Diseases 、《中国组织工程研究与临床康复》、《中国神经再生研究(英文版)》、《病毒学报》等国内外多家学术期刊编委(Editorial Board Member)

6. 2010 武汉市东湖高新技术开发区“3551人才”、武汉市第十届华创会“华创杯”优秀项目奖、美国圣地亚哥3Dbiotek“三维细胞培养行业国际知名专家”

7. 2012 湖北省“省级计划”入选者,武汉市有突出贡献中青年专家

8. 2015 武汉欧美同学会生物医药分会 副会长

9. 2015起 国家科学技术奖励评审专家、科技部国际重大合作项目终审专家、教育部评审专家

10. 2018 中国人民解放军全军科技进步奖(排名第二)

11. 2019 中华预防医学会科技进步奖(排名第二)