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刘滨磊

发布时间:2020-04-11 阅读人数:

导师姓名:刘滨磊

导师类型:博士生导师

出生日期:1962/12/28

职称:教授

个人简介:

   刘滨磊,男,1962年,博导、湖北澳门各大游戏平台网址大学特聘教授、湖北省计划。其带领团队研发出新型溶瘤II型单纯疱疹病毒,获得国家药品监督管理局药物临床试验批件(批件号:2018L02743),已完成I期临床试验。获得973、863、十二五支撑项目、自然科学基金等资助。累计发表30多篇科研论文。

所在学院:生物工程与食品学院

专业:生物工程

研究方向:溶瘤病毒、肿瘤生物治疗

主讲硕士生课程:

主讲博士生课程:

科研项目:

1、2018年重大新药创制专项,2018ZX09733002,基因治疗溶瘤病毒1类新药的临床前和临床研究,2018-01至2021-12,在研,子课题负责人;

2、2015-2018,国家自然科学基金面上项目,《择瘤繁殖并表达绿色荧光蛋白的单纯疱疹病毒检测循环肿瘤细胞》,批准号:81472013,项目负责人;

3、2014-2017,“十二五”国家科技支撑计划,《恶性肿瘤靶基因捕获技术等转化医学平台》,批准号:2014BAI09B04,子课题负责人;

4、2012-2015, 973,项目《恶性肿瘤免疫负调控网络》,批准号:2012CB917104,子课题负责人

5、2012-2015, 863,项目《疫苗研发关键技术及产品研发》,批准号:2012AA02A407, 子课题负责人

科研成果:

(1)Wen Zhang, Xiao Hu, Jing Liang, Yujie Zhu, Beibei Zeng, Lin Feng, Changyun Zhao, Shangmei Liu*, Binlei Liu*, and Kaitai Zhang*. oHSV2 Can Target Murine Colon Carcinoma by Altering the Immune Status of the Tumor Microenvironment and Inducing Antitumor Immunity. Molecular Therapy Oncolytics, 2020, vol. 16;

(2) Zhu Yujie#; Hu Xiao#; Feng Lin; Yang Zhenrong; Zhou Lulin; Duan Xinchun; Cheng Shujun; Zhang Wen*; Liu Binlei*; Zhang Kaitai*; Enhanced Therapeutic Efficacy of a Novel Oncolytic Herpes Simplex Virus Type 2 Encoding an Antibody Against Programmed Cell Death 1, Molecular Therapy-Oncolytics, 2019, 15: 201-213.

(3) Wang Yang#; Zhou Xiaobing#; Wu Zhen#; Hu Han#; Jin Jing#; Hu Yanping; Dong Yuting; Zou Jianwen; Mao Zeyong; Shi Xiaotai; Huo Yan; Lyu Jianjun; Fang Zhizheng; Zhang Wen; Zhu Yujie; Li Bo*; Liu Binlei*; Preclinical Safety Evaluation of Oncolytic Herpes Simplex Virus Type 2, Human Gene Therapy, 2019, 30: 651-660.

(4) Yang, W., Jing, J., Zhen, W., Sheng, H., Han, H.,Ning, Z. et al. (2018). Stability and anti-tumor effect of oncolytic herpes simplex virus type 2. Oncotarget 9, 24672-24683.

(5) Han Hu#, Ziyi Zhang#, Runyang Wang, Yang Wang, Jing Jin, Linkang Cai, Junhan Yang, Haixiao Duan, Zhen Wu, Zhizheng Fang, Binlei Liu*. BGC823 Cell Line with the Stable Expression of iRFP720 Retains Its Primary Properties with Promising Fluorescence Imaging Ability. DNA and Cell Biology, 2020, DOI: 10.1089/dna.2019.5057

(6) Cai Linkang#; Hu Han#; Duan Haixiao; Li Yuying; Zou Zongxing; Luo Kailun; Zhang Ziyi; Yang Junhan; Jin Jing; Chen Ying; Ke Zonghuang; Fang Zongyao; Liu Qiong; Hong Xiaoqian; Hu Shen; Liu Binlei*; The construction of a new oncolytic herpes simplex virus expressing murine interleukin-15 with gene editing technology, Journal Of Medical Virology, 2020, Accepted Author Manuscript. doi:10.1002/jmv.25691

(7) Yang H. #; Peng T. #; Li J. #; Wang Y.; Zhang W.; Zhang P.; Peng S.; Du T.; Li Y.; Yan Q. *; Liu Binlei*; Treatment of colon cancer with oncolytic herpes simplex virus in preclinical models, Gene Therapy, 2016, 23: 450-459.