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苏正定

发布时间:2020-04-11 阅读人数:

导师姓名:苏正定

导师类型:博士生导师

出生日期:1965/2/20

职称:教授

个人简介:

    省特聘专家和特聘教授。历任加拿大国家生物技术研究院、滑铁卢大学、美国St Jude儿童研究医院高级研究员和教授,承担重大项目共12项。在PNAS、JACS等期刊发表论文80余篇,获15项发明专利授权 (hbut-peps-lab.org)。

所在学院:生物工程与食品学院

专业:生物工程

研究方向:蛋白质工程与生物制药

主讲硕士生课程:高级生化与分子生物学;代谢工程

主讲博士生课程:高级生化与分子生物学

科研项目:

1. 湖北省科技厅,创新专项重大项目,基于植物甾醇半生物法合成抗癌药物醋酸癌比特龙关键技术研发,100万元(财政),1100万元(横向),2017-01至2019-12,在研,主持。

2. 武汉市自然科学基金,重点项目,2015060101010033,肝癌早期诊断和靶向抗癌药物设计,15万元,2015-01至2017-12, 结题, 主持。

3. 武汉东湖国家高新区,光谷3551人才计划,长效抗2-型糖尿病多肽药物设计, 200万元,2015-01 至 2020-12, 在研,主持。

4. 国家自然科学基金, 面上项目,81072582, 维生素 B12 介导生物纳米载体口服传递肠促胰岛素多肽药物 ,32万元,2011-01至2013-12;结题, 国际合作。

5. 科技部,“十三五“重大专项新药创制项目,2013ZX09103003-018, 长效胰高血糖素样肽-1(GLP-1)在灵长目动物体内药代动力学性质及安全性评价, 109万元,结题,国际合作。

6. 科技部,“十一五“重大专项新药创制项目,2009ZX09103, 依赖血浆凝血酶的肽缓释新策略设计优化长效2型糖尿病多肽药物,2009-01至2010-12, 110万元, 结题,国际合作。

科研成果:

1. Ni Pi, Meng Gao, Xiyao Cheng, Huili Liu, Zhengkun Kuang, Zixin Yang, Jing Yang, Bailing Zhang, Yao Chen, Sen Liu, Yongqi Huang,* and Zhengding Su*. Recombinant Butelase-Mediated Cyclization of the p53-Binding Domain of the Oncoprotein MdmX-Stabilized Protein Conformation as a Promising Model for Structural Investigation. Biochemistry, 2019, 58, 3005−3015

2. Fei Peng, Xiyao Cheng, Hongwei Wang, Shikui Song, Tian Chen, Xin Li, Yijun He, Yongqi Huang, Sen Liu, Fei Yang*, Zhengding Su*, Structure-based reconstruction of a Mycobacterium hypothetical protein into an active δ5–3-ketosteroid isomerase. BBA - Proteins and Proteomics, 1867 (2019): 821–830

3. Chao Feng, Yinong Huang,*, Wangxiao He, Xiyao Cheng, Huili Liu, Yongqi Huang, Bohan Ma, Wei Zhang, Chongbing Liao, Weihui Wu, Yongping Shao, Dan Xu, Zhengding Su,* and Wuyuan Lu*, Tanshinones: First-in-Class Inhibitors of the Biogenesis of the Type 3 Secretion System Needle of Pseudomonas aeruginosa for Antibiotic Therapy. ACS Cent. Sci. 2019, 5, 1278−1288

4. Jingjing Zhou#, Chengbin Qiu, Ni Pi , Sicong Li, Xiyao Cheng, Lei Zhang, Yao Chen, Yongqi Huang*, Yuhui Sun*, Su Zhengding*, A Protein Biosynthesis Machinery Strategy for Identifying P53PTC‐Rescuing Compounds as Synergic Antitumor Drugs. ChemistrySelect 2018, 3: 11048

5. Qin Lingyun#, Liu Huili#, Chen Rong#, Zhou Jingjing, Cheng Xiyao, Chen Yao, Huang Yongqi*, Su Zhengding*, Effect of the Flexible Regions of the Oncoprotein Mouse Double Minute X on Inhibitor Binding Affinity. Biochemistry, 2017, 56(44): 5943-5954

6. Chen Rong#, Zhou Jingjing, Qin Lingyun, Chen Yao, Huang Yongqi, Liu Huili*, Su Zhengding*, A Fusion Protein of the p53 Transaction Domain and the p53-Binding Domain of the Oncoprotein MdmX as an Efficient System for High-Throughput Screening of MdmX Inhibitors. Biochemistry, 2017, 56(25): 3273-3282

7. Nian Cheng, Lei Yang, Ning Dai, Zhongping Hu, Fan Yang, Rong Chen, Xiyao Cheng, Jingjing Zhou, Yongqi Huang*, Zhengding Su*. A novel strategy to prepare the precursor peptide of liraglutide, Process Biochemistry, 2017,62: 10-15