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汪洋

发布时间:2020-04-11 阅读人数:

导师姓名:汪洋

导师类型:硕士生导师

出生日期:1983/11/17

职称:副教授

个人简介:

   汪洋,副教授,博士,硕士生导师,湖北省“省级计划”学子, “3551光谷人才计划”获得者,湖北省“双创战略团队”核心成员。研究方向为溶瘤病毒(OH2)抗肿瘤机制研究;I类抗肿瘤新药OH2的临床前研究和临床试验。

所在学院:生物工程与食品学院

专业:生物工程

研究方向:抗肿瘤生物药

主讲硕士生课程:

主讲博士生课程:

科研项目:

1. 牛支原体脂质相关膜蛋白(LAMPs)诱导胎牛肺细胞IL-1β释放的分子机制研究,国家自然科学基金青年基金,31502090, 2016年1月至2018年12月, 主持,20万

 2. 溶瘤II型单纯疱疹病毒的肺癌治疗性疫苗的研发,横向课题,2016229,2016年1月至2017年12月,主持,30万

 3. 择瘤繁殖并表达绿色荧光蛋白的重组II型单纯疱疹病毒检测循环肿瘤细胞试剂盒的开发,横向课题,2016278,2016年1月至2017年12月,主持, 20万

 4. 病毒激活免疫细胞(VAK)抗肿瘤免疫治疗技术的研发,横向课题,2017232,2017年1月至2018年12月,主持,150万

科研成果:

1) Preclinical safety evaluation of oncolytic herpes simplex virus type 2. Yang Wang, Xiaobing Zhou, Zhen Wu, Han Hu, Jing Jin, Yanping Hu, Yuting Dong, Jianwen Zou, Zeyong Mao, Xiaotai Shi, Yan Huo, Jianjun Lyu, Zhizheng Fang, Wen Zhang, Yujie Zhu, Bo Li, Binlei Liu. Human Gene therapy, 2018, doi: DOI: 10.1089/hum.2018.170.

2) Stability and anti-tumor effect of oncolytic herpes simplex virus type 2. Yang Wang, Jing Jin, Zhen Wu, Sheng Hu, Han Hu, Zhifeng Ning, Yanfei Li, Yuting Dong, JianwenZou, Zeyong Mao, Xiaotai Shi, Huajun Zheng, Shuang Dong, Fuxing Liu, Zhizheng Fang, Jiliang Wu and Binlei Liu. Oncotarget, 2018, 9:24672-24683.

3) Transcription analysis on response of porcine alveolar macrophages to Haemophilus parasuis. Yang Wang, Chong Liu, Ying Fang, Xiaoli Liu, Wentao Li, Shuqing Liu, Yingyu Liu, Yuxi Liu, Catherine Charreyre, Jean Christophe Audonnet, Pin Chen, Qigai He. BMC Genomics, 2012, 13:68.

4) Mycoplasma bovis-derived lipid-associated membrane proteins activate IL-1β production through the NF-κB pathway via Toll-like receptor 2 and MyD88. Yang Wang, Suli Liu, Yuan Li, Qi Wang, Jiari Shao, Ying Chen, Jiuqing Xin, Developmental and Comparative Immunology 2016, 55: 111-118

5) Porcine Coronin 1A contributes to inhibit NF-κB activation during Haemophilus parasuis infection. Chong Liu#, Yang Wang #, Hengling Zhang, Shuang Cheng, Xiaoli Liu, Xiaofei Wang, Catherine Charreyre, Jean Christophe Audonnet, Pin Chen, Rui Zhou, Huanchun Chen, Qigai He*.Plos One  2014, 8:e103904

6)Mmm-derived lipid-associated membrane proteins activate IL-1b production through the NF-κB pathway via TLR2, MyD88, and IRAK4. Yang Wang, Qi Wang, Yuan Li, Ying Chen, Jiari Shao, Nick Nwankpa, Chunyan Li, Jiuqing Xin. Scientific Reports, 2017,7:4349.

7)Changes in pathogenicity and immunogenicity of Mycoplasma mycoides subsp. mycoides strains revealed by comparative. Yuan Li#, Yang Wang #, Wang Rui, Yongqiang Zhu, Suli Liu, Qi Wang, Jiari Shao, Ying Chen, Liping Gao, Changping Zhou, Henggui Liu1, Xiumei Wang, Huajun Zheng and Jiuqing Xin. Scientific Reports,  2016,6:19081.

8)P19 contribute to Mycoplasma mycoides subsp. mycoides adhesion to EBL cells. Yumei Zhou #, Yang Wang#, Yuan Li , Nwankpa Nick , Xiaohui Zou 1,Fan Bai , Jindi Wu , Jiuqing Xin. Microbial Pathogenesis. 2016, 93:13-21

9) Loop-mediated isothermal amplification targeting the apxIVA gene for detection of Actinobacillus pleuropneumoniae. Yang Wang, Pin Chen, Haibing Guo, Yang Chen, Hui Liu, Qigai He. FEMS Microbiology Letters, 2009, 300: 83-89

10) Development and evaluation of loop-mediated isothermal amplification for rapid detection of Haemophilus parasuis. Yang Wang, Ying Fang, Yingyu Liu, Pin Chen, Wentao Li, Shuqing Liu, Haoyong Zou, Qigai He. FEMS Microbiology Letters, 2010, 313:54-60.

11) Molecular cloning and characterization of a new variable surface protein in a Mycoplasma bovis Hubei-1 Strain. Xiaohui Zou, Yuan Li, Yang Wang, Yumei Zhou, Yang Liu, Jiuqing Xin*. Plos One, 2013, 8:69644

12) Proteomic analysis of porcine  alveolar macrophages infected with porcine circovirus type 2. Shuang Cheng, Min Zhang, Wentao Li, Yang Wang, Yingyu Liu, Qigai He. Journal of Proteomics, 2012, 75:3258-3269

13) Transcription analysis of the porcine alveolar macrophage response to porcine cirovirus type 2, Wentao Li, Shuqing Liu, Yang Wang, Feng Deng, Weidong Yan, Kun Yang, Huanchun Chen, Qigai He, Catherine Charreyre, Jean-Christophe Audoneet. BMC Genomics,2013 14:353

14) Transcriptional Profiling of Haemophilus parasuis SH0165 Response to Tilmicosin. Yingyu Liu, Pin Chen, Yang Wang, Wentao Li, Shuang Cheng, Chunmei Wang, Anding Zhang, and Qigai He. Microbial Drug Resistance, 2012, 18 (6):604-15

15) Porcine reproductive and respiratory syndrome virus nonstructural protein 2 contributes to NF-κB activation. Ying Fang, Liurong Fang, Yang Wang, Yingying Lei, Rui Luo, Dang Wang, Huanchun Chen and Shaobo Xiao. Virology Journal, 2012, 9:83.

16) Broad activity against porcine bacterial pathogens displayed by two insect antimicrobial peptides moricin and cecropin B. Han Hu, Chunmei Wang, Xiaozhen Guo,Wentao Li, Yang Wang, Qigai He. Molecules and Cells, 2013, 35:106-114.

17) Efficacy of single dose of an inactivated porcine circovirus type 2 (PCV2) whole-virus vaccine with oil adjuvant in piglets. Kun Yang, Wentao Li, Huihui Niu, Weidong Yan, Xiaoli Liu, Yang Wang, Shuang Cheng, Xugang ku and Qigai He. Acta Veterinaria Scandinavica, 2012, 54,67.

18) Treatment of colon cancer with oncolytic herpes simplex virus in preclinical models. H Yang, T Peng, J Li, Yang W, W Zhang, P Zhang, S Peng, T Du, Y Li, Q Yan and B Liu. Gene Therapy, 2016,23: 450-459