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张雷

发布时间:2020-04-11 阅读人数:

导师姓名:张雷

导师类型:硕士生导师

出生日期:1981/2/22

职称:副教授

个人简介:

   教育经历:

   2003/09-2011/03,武汉大学,生命科学学院,硕博连读

   1999/09-2003/06,武汉大学,生命科学学院,本科

   工作经历:

   2014/11-至今,湖北澳门各大游戏平台网址大学,生物工程学院;

   2011/03-2012/08, Case Western Reserve University, Department of Pharmacology,(Cleveland, USA) Postdoc;

   2012/08-2014/11, National University of Singapore, Faculty of Science, (Singapore)Research Fellow;

   2018.02-2019. 03 Case Western Reserve University, Department of Pharmacology, Visiting Scholar

所在学院:生物工程与食品学院

专业:细胞生物学

研究方向:DNA损伤应答及真核细胞基因组稳定性维持的细胞生物学及生物化学基础 。 肿瘤细胞转移的表观遗传学机制。 恶性肿瘤临床检测标志物及新的抗肿瘤药物靶点的开发。

主讲硕士生课程:

主讲博士生课程:

科研项目:

1. 湖北省“省级”计划“学子”

2. 国家自然科学基金:”泛素交联酶UbcH7在DNA损伤应答中的功能和机制分析”(31501150) 主持

3. 湖北省武汉市科技局“晨光计划”:一种以UbcH7为靶点的对抗肿瘤放化疗耐受的短肽药物的研发(2016070204010140) 主持

4. 武汉东湖高新区 “3551光谷人才计划” 多肽类抗肿瘤放化疗辅助联用药物“优必希”的研发。  主持

科研成果:

1,  #Xiangzi Han #Lei Zhang , , #Jinsil Chung, Franklin Mayca Pozo, Amanda

Tran, Darcie D. Seachrist, James W. Jacobberger, Ruth A. Keri, Hannah Gilmore,  

Youwei zhang. “UbcH7 regulates 53BP1 stability and DSB repair”, Proc Natl Acad

Sci U S A(IF=9.67). 111(49):17456–17461, 2014 Dec 9. (Co-First Author)

2,He R, Xie X, Lv L, Huang Y, Xia X, Chen X, *Zhang L. “Comprehensive investigation of aberrant microRNAs expression in cells culture model of MnCl2-induced neurodegenerative disease.” Biochem Biophys Res Commun 2017 Apr 29;486(2):342-348. doi: 10.1016/j.bbrc.2017.03.041.

3,Qing G, Lu Q, Xiong Y, Zhang L, Wang H, Li X, Liang X, Sun T. “New Opportunities and Challenges of Smart Polymers in Post-Translational Modification Proteomics.” Adv Mater(IF=19.791),2017 May;29(20). doi: 10.1002/adma.201604670. Epub 2017 Jan 23.

4,Yifeng Gu, *Lei Zhang, Xiaowu Chen, “Differential expression analysis of Paralichthys olivaceus microRNAs in adult ovary and testis by deep sequencing”. General and Comparative Endocrinolog, 204(1) :181-184,2014 Aug. (corresponding author)

5,GOLT1A-KISS1 Fusion Is Associated With Metastasis in Adenoid Cystic Carcinomas. Lei Zhang , Anyi Cheng , Yanan Yu , Nengxing Zou , Wenxiu Wang , Linyue Lv , Xiaoxia Guo , Mingyue Chen , Youwei Zhang Biochem Biophys Res Commun ,2020 Mar 17

6.   Lv L.Y., Chen W.R., Cheng A.Y., Yu Y.N., Wen C., *Zhang L. Aberrant

glycosylation in a metastatic cell model of salivary adenoid cystic carcinoma,

Basic & Clinical Pharmacology & Toxicology, 121 (Suppl. 5), 1–38

7.  Lv L.Y., Wen C., Chen W.R., Cheng A.Y., Yu Y.N., *Zhang L. Identification of

metastasis-associated gene fusions in salivary adenoid cystic carcinoma. Basic &

Clinical Pharmacology & Toxicology, 121 (Suppl. 5), 1–38

8. Zhang, L.; Zhang, Y. Influenza Viral Infection is a High-Risk Factor for

Developing Coronavirus Disease 2019 (COVID-19). Preprints 2020, 2020030307 (doi: 10.20944/preprints202003.0307.v1)